An overview of new antiviral drugs under research for chronic hepatitis B / 临床肝胆病杂志

Chronic hepatitis B caused by hepatitis B virus (HBV) infection remains a major public health problem worldwide, and functional cure and even complete cure of chronic hepatitis B are the goals pursued by drug researchers. At present, widely used nucleos(t)ide analogues and interferon therapy fail to achieve a high cure rate. This article reviews the anti-HBV drugs/therapies under research, including viral entry inhibitors, capsid inhibitors, HBsAg inhibitors, immune modulators, gene editing, and cell therapies, and summarizes related clinical research findings, so as to clarify the latest advances in this field and the new ideas in drug research and development.